No matter how much time we spend in prayer and in God's Word, we can only speculate about many of the circumstances in our lives.  Once in Heaven, we will understand perfectly the things that confuse us now, like the reasons behind all our hurts, disappointments, and trials.  Even then, we won't be omniscient, that is, all-knowing, like God, but He will enable us to understand Him as He understands us now.  And we can start on that right now!